Super Cajun Chicken and Shrimp Lasagna

This Super Cajun Chicken and Shrimp Lasagna is a flavorful twist on a classic comfort food. The Cajun seasoning adds a spicy kick to the chicken and shrimp, while the creamy tomato sauce and cheese make for a delicious and satisfying dish. The lasagna noodles provide a comforting texture and the vegetables add a pop of color and nutrition. This recipe is perfect for a family dinner or potluck, and it can be prepared in advance and reheated for easy leftovers.

Nutrition Facts: Serving size: 1/12th of the lasagna Calories: 320 Total fat: 14g Saturated fat: 7g Cholesterol: 97mg Sodium: 624mg Total carbohydrates: 26g Dietary fiber: 2g Sugars: 5g Protein: 22g


  • 9 lasagna noodles, cooked according to package directions
  • 1/2 pound cooked and shredded chicken
  • 1/2 pound cooked and peeled shrimp
  • 1 tablespoon Cajun seasoning
  • 2 tablespoons butter
  • 1 red bell pepper, diced
  • 1 green bell pepper, diced
  • 1 onion, diced
  • 3 cloves garlic, minced
  • 1 can (14.5 ounces) diced tomatoes, drained
  • 1 can (8 ounces) tomato sauce
  • 1/4 cup chicken broth
  • 1/4 cup heavy cream
  • 1/2 teaspoon salt
  • 1/2 teaspoon black pepper
  • 1/4 teaspoon cayenne pepper
  • 1/4 teaspoon paprika
  • 1/4 teaspoon garlic powder
  • 1/2 cup grated Parmesan cheese
  • 1/2 cup shredded mozzarella cheese

Preparation time: 30 minutes Cooking time: 40 minutes


  1. Preheat the oven to 375°F (190°C). Grease a 9×13-inch baking dish.
  2. In a large bowl, mix together the chicken, shrimp, and Cajun seasoning. Set aside.
  3. In a large skillet, melt the butter over medium heat. Add the red and green bell peppers, onion, and garlic, and cook until the vegetables are soft, about 5 minutes.
  4. Add the diced tomatoes, tomato sauce, chicken broth, heavy cream, salt, black pepper, cayenne pepper, paprika, and garlic powder. Stir to combine and bring the mixture to a simmer.
  5. Reduce the heat to low and let the mixture simmer for 10 minutes.
  6. Layer 3 lasagna noodles in the bottom of the prepared baking dish. Spread one-third of the tomato mixture over the noodles, then sprinkle one-third of the chicken and shrimp mixture on top. Sprinkle with one-third of the Parmesan cheese and mozzarella cheese. Repeat the layering process two more times, ending with a layer of cheese on top.
  7. Cover the baking dish with foil and bake for 25 minutes.
  8. Remove the foil and bake for an additional 15 minutes, or until the cheese is melted and bubbly.
  9. Let the lasagna cool for 10 minutes before slicing and serving.